Latest Research on Alzheimer’s Prevention
VITAMIN D SUFFICIENCY
Researchers conclude that vitamin D sufficiency helps remove amyloid-beta plaque from the aging brain, across the blood-brain barrier, helping to prevent the excessive buildup that causes Alzheimer’s disease.
(The buildup in the brain, of amyloid-beta plaque is ordinarily controlled by transporter proteins and vitamin D. Although levels of these protein transporters increase with age, production tends to fail eventually. Low levels of vitamin D have been linked with age-related declines in memory and cognition, and with an increased risk of Alzheimer’s.)
The team found that vitamin D injections in mice appear to help regulate protein expression and cell signaling, which helps prevent plaque buildup and the onset of Alzheimer’s disease and dementia. The implication is that maintaining sufficient vitamin D levels with advancing age may provide some preventive benefit, and a potential therapy, for these brain disorders.
This newly released study will be published in a future issue of the journal, Fluids and Barriers of the CNS. It is available early at http://bit.ly/nmFQyC without fee.
GRAPESEED POLYPHENOLS
A new study found that grapeseed polyphenol, a natural antioxidant, suppresses the creation of a specific form of beta-amyloid peptide – a substance in the brain long known to cause the neurotoxicity associated with Alzheimer’s disease – and therefore confirms, according to the researchers, previous research suggesting that grapeseed polyphenol may be an effective treatment for people at risk for the disease to prevent its development or retard its progression.
The authors stress that for grape-derived polyphenols to be effective, it will be necessary to find a biomarker for those at risk, although it may also be beneficial for those in the early stages of the disease. The study is significant because it is the first to examine the effect of this substance on these destructive peptides, illustrating the mechanism behind the apparent protective benefit, and because it was conducted on living subjects, namely mice. However, research is now being conducted to confirm that the results hold true for humans. The full-text of this just-released study is not yet available but will be published in a future issue of the Journal of Alzheimer’s Disease.
How Can Dark Chocolate Help You?
Dark chocolate may combat exercise-induced oxidative stress
Consuming flavonoid-rich dark chocolate prior to exercise may decrease the potential muscle damaging effects of oxidative stress, suggests a new study.
Dark chocolate containing 70% cocoa was associated with blunting oxidative stress after exercise, measured as a reduction in levels of a compound called F2-isoprostane, according to findings published in European Journal of Nutrition.
“We believe that the small effects observed here could be physiologically important, but arise from cocoa-induced metabolic changes leading to modulation of the major plasma constituents,” wrote scientists led by Glen Davison from Aberystwyth University in Wales.
“In addition, dark chocolate was effective at blunting the exercise-induced increase in plasma total antioxidant status observed in the other trials, providing support for the idea that the elevated total antioxidant status on the dark chocolate trial has physiological significance.”
Stress
Oxygen-breathing organisms naturally produce reactive oxygen species (ROS), which play an important role in a range of functions, including cell signalling. However, over production of these ROS from smoking, pollution, sunlight, high intensity exercise, or simply ageing, may overwhelm the body’s antioxidant defences and lead to oxidative stress.
Oxidative stress has been linked to an increased risk of various diseases including cancer, Alzheimer’s, and cardiovascular disease.
The researchers also noted that extended periods of exercise are also often used to model physical stress, and that this may be eased by consumption of a polyphenol-rich dark chocolate.
Choc-full of benefits?
According to their new findings, the effects were seen after only one 100 grams serving of the dark chocolate.
“It is possible, therefore, that greater blunting of oxidative stress responses would be observed with a different timing and/or quantity of dark chocolate ingestion, although this will require further investigation,” wrote the researchers.
The health benefits of polyphenols from cocoa have been gathering increasing column inches in the national media. To date studies have reported potential benefits for cardiovascular health, skin health, and even brain health.
The majority of science into the potential benefits of cocoa have revolved around cardiovascular benefits of the flavanols (also known as flavan-3-ols or catechins), and particularly the monomeric flavanol (-)epicatechin.
Study details
Davison and his co-workers recruited 14 healthy men to participate in their study. Volunteers were asked to consume 100 grams of dark chocolate, a control bar, or nothing. Two hours later they were required to cycle for 2.5 hours at 60 percent of the maximal oxygen uptake level.
Results showed that intake of the dark chocolate resulted in an increase in antioxidant status before the cycling, and reduced levels of F2-isoprostane one hour after the cycling had finished, compared with the control bar.
Insulin levels were also increased before the trial and after cycling for men who consumed the dark chocolate and this was associated with a “better maintenance of plasma glucose concentration”, added the scientists.
On the other hand, there were no changes in markers of immune response, which is known to be affected by rigorous exercise.
“These results with acute dark chocolate consumption are similar to those observed following 2 weeks of daily dark chocolate ingestion,” wrote the researchers.
The other scientists were affiliated with Loughborough University and the University of Newcastle in the UK, and the Nestle Research Center in Lausanne, Switzerland. The study was funded by the Nestle Research Center.
Source: European Journal of Nutrition
“The effect of acute pre-exercise dark chocolate consumption on plasma antioxidant status, oxidative stress and immunoendocrine responses to prolonged exercise”
Authors: G. Davison, R. Callister, G. Williamson, K.A. Cooper, M. Gleeson
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Cocoa Flavonoid Formulas Offer Support Ranging from Natural Mental Health to Endurance Training
InSight Natural and InSight HT contain antioxidant polphenols/flavonoids from the unroasted cocoa nib and have been used successfully by athletes as part of endurance training, as well as individuals seeking to support healthy brain function, concentration levels, mental clarity and a more positive state of mind.
To learn more about how these cocoa polyphenol/flavonoid formulations can make a difference in your life, click here: InSight Natural, or InSight HT.
MyKidsPotential.com Help Your Child Succeed
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is our new website devoted to Kids Potential – the first kids vitamin patented for “learning, academic & behavioral functioning.”* (Patent 7,771,756)
Kids Potential is:
- Dispensed in schools as part of a program to improve learning, test scores & behavior
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Study: Poor Childhood Diet Linked to Low IQ – Vitamins Can Help
A diet high in fats, sugars, and processed foods in early childhood may result in lower IQ scores, while a diet rich in healthy foods packed with vitamins and nutrients may work in reverse, suggests new research.
The study, published in BMJ’s Journal of Epidemiology and Community Health, reports a “weak but novel” association between dietary patterns in early childhood, and general intelligence assessed at eight and a half years of age.
The results of the study suggest that the eating habits in early childhood – particularly up until the age of three – may play a role in shaping the development of the brain, and thus affect behaviour, learning performance and IQ in later life.
“In this population of contemporary British children, a poor diet, associated with increased intake of processed foods, fat and sugar, in early childhood may be associated with lower IQ at the age of 8.5 years. In addition, a concurrent healthy diet may be associated with higher IQ,” said the researchers, led by Dr Kate Northstone from the Department of Social Medicine at the University of Bristol, UK.
The importance of healthy diets
Commenting on the new study, Barbara Gallani director of food safety and science at the UK’s Food and Drink Federation told FoodNavigator that it would not be surprising if a healthy, balanced diet is important in IQ development, “just like it is generally for children’s health and growth.”
She added that it is important for everyone, not just children, to eat a wide variety of foods, noting that it is possible eat a healthy diet and still include some ‘treat’ foods.
Gallani said that food manufacturers are leading the way when it comes to providing clear labelling on foods, as well as changing recipes to make old favourites healthier, which “makes it even easier for parents to choose a balanced diet that’s right for their families.”
An intelligent diet
Northstone and her colleagues noted that previous research investigating possible associations between nutrition and IQ in children have tended to focus on the use of dietary supplements or on intakes of specific nutrients.
For example, several studies have examined the effects of vitamin supplementation on IQ in children, with mixed results.
However, the authors said that studies investigating the long-term effects of nutrition on intelligence are sparse and conflicting. “In particular …there appears to be little known about the effects of the diet in early childhood on general intelligence later in life,” they said.
“We do not eat foods in isolation, rather consuming combinations of foods in meals and snacks,” explained the authors.
“Assessing dietary patterns as opposed to individual foods or nutrients allows to us take into account these intercorrelations, which may otherwise be overlooked,” they said.
The new cross sectional study, based on the Avon Longitudinal Study of Parents and Children (ALSPAC), examined the links between dietary patterns through early and mid-childhood (3 to 8.5 years) and IQ assessed at 8.5 years of age.
Study details
The researchers measured dietary patterns using principal-components analysis (PCA), which provide overall summaries of dietary intake. The diet data, measured at the ages of 3, 4, 7 and 8.5 was then examined for any associations between diet and IQ in nearly 4,000 children.
Three consistent dietary patterns were found from PCA at each time point: a ‘processed’, ‘traditional’ and ‘health conscious’ pattern.
The ‘processed’ pattern was illustrated by foods containing high fat and sugar content and by higher intakes of processed and convenience foods. The ‘traditional’ pattern was associated with consumption of generally home cooked meat, poultry, potato and vegetables, whilst the ‘health-conscious’ pattern was predominantly made up from high intakes of salads, fruit, vegetables, fish, pasta and rice.
“On minimal adjustment, all dietary pattern scores were associated with IQ with the exception of the ‘traditional’ pattern,” said the authors.
Before adjustment for confounding factors (such as parental influence, social and economic status, and other environmental factors) the researchers observed that the ‘processed’ food pattern was negatively associated with IQ at all ages, while the ‘health-conscious’ pattern at all ages were positively associated with IQ.
However, after adjustment for a wide variety of potential confounding factors, they reported that many associations between IQ and dietary pattern were lost, and those that remained (‘processed’ pattern at three years and ‘health-conscious’ patterns at 8.5 years) “were markedly attenuated”, according to the authors.
For the remaining relationships (after full adjustment) the ‘processed’ food pattern at 3 years was found to be such that a one point increase in the PCA score resulted in an almost two-point decrease in IQ at 8.5 years. Whilst the ‘health-conscious’ pattern was associated with an increased in IQ of 1.20 points per one point increase in PCA pattern score.
Interpretation
Northstone and colleagues said that the results of the study suggest a more “long-term effect of diet on the child’s ability to ‘learn’,” they noted that this could be in part be explained by favourable growth of the brain in early childhood – They noted that it is known that the brain grows at its fastest rate during the first 3 years of life.
“Studies have shown that head growth during this time is associated with cognitive outcome, and it is possible that good nutrition during this early period may encourage optimal brain growth,” said the authors.
However, they added that given the levels of attenuation seen in the effect sizes when adjusted for confounding factors, “we cannot exclude the possibility of residual confounding.”
Source: Journal of Epidemiology and Community Health
Published online ahead of print, doi: 10.1136/jech.2010.111955
“Are dietary patterns in childhood associated with IQ at 8 years of age? A population-based cohort study”
K. Northstone, C. Joinson, P. Emmett, A. Ness, T. Paus
=================================
Kids Potential is the first kids multi-vitamin patented as a “nutritional supplement to enhance learning, academic and behavioral functioning.” Patent #7,771,756
Over 8 years of experience in public schools shows that Kids Potential has a positive impact on learning, academic and behavioral performance in children.
Learn more here: Kids Potential.
Buy Kids Potential by clicking here.
Poor childhood diet linked to low IQ, suggests study
Poor childhood diet linked to low IQ, suggests study
A diet high in fats, sugars, and processed foods in early childhood may result in lower IQ scores, while a diet rich in healthy foods packed with vitamins and nutrients may work in reverse, suggests new research.
The study, published in BMJ’s Journal of Epidemiology and Community Health, reports a “weak but novel” association between dietary patterns in early childhood, and general intelligence assessed at eight and a half years of age.
The results of the study suggest that the eating habits in early childhood – particularly up until the age of three – may play a role in shaping the development of the brain, and thus affect behaviour, learning performance and IQ in later life.
“In this population of contemporary British children, a poor diet, associated with increased intake of processed foods, fat and sugar, in early childhood may be associated with lower IQ at the age of 8.5 years. In addition, a concurrent healthy diet may be associated with higher IQ,” said the researchers, led by Dr Kate Northstone from the Department of Social Medicine at the University of Bristol, UK.
The importance of healthy diets
Commenting on the new study, Barbara Gallani director of food safety and science at the UK’s Food and Drink Federation told FoodNavigator that it would not be surprising if a healthy, balanced diet is important in IQ development, “just like it is generally for children’s health and growth.”
She added that it is important for everyone, not just children, to eat a wide variety of foods, noting that it is possible eat a healthy diet and still include some ‘treat’ foods.
Gallani said that food manufacturers are leading the way when it comes to providing clear labelling on foods, as well as changing recipes to make old favourites healthier, which “makes it even easier for parents to choose a balanced diet that’s right for their families.”
An intelligent diet
Northstone and her colleagues noted that previous research investigating possible associations between nutrition and IQ in children have tended to focus on the use of dietary supplements or on intakes of specific nutrients.
For example, several studies have examined the effects of vitamin supplementation on IQ in children, with mixed results.
However, the authors said that studies investigating the long-term effects of nutrition on intelligence are sparse and conflicting. “In particular …there appears to be little known about the effects of the diet in early childhood on general intelligence later in life,” they said.
“We do not eat foods in isolation, rather consuming combinations of foods in meals and snacks,” explained the authors.
“Assessing dietary patterns as opposed to individual foods or nutrients allows to us take into account these intercorrelations, which may otherwise be overlooked,” they said.
The new cross sectional study, based on the Avon Longitudinal Study of Parents and Children (ALSPAC), examined the links between dietary patterns through early and mid-childhood (3 to 8.5 years) and IQ assessed at 8.5 years of age.
Study details
The researchers measured dietary patterns using principal-components analysis (PCA), which provide overall summaries of dietary intake. The diet data, measured at the ages of 3, 4, 7 and 8.5 was then examined for any associations between diet and IQ in nearly 4,000 children.
Three consistent dietary patterns were found from PCA at each time point: a ‘processed’, ‘traditional’ and ‘health conscious’ pattern.
The ‘processed’ pattern was illustrated by foods containing high fat and sugar content and by higher intakes of processed and convenience foods. The ‘traditional’ pattern was associated with consumption of generally home cooked meat, poultry, potato and vegetables, whilst the ‘health-conscious’ pattern was predominantly made up from high intakes of salads, fruit, vegetables, fish, pasta and rice.
“On minimal adjustment, all dietary pattern scores were associated with IQ with the exception of the ‘traditional’ pattern,” said the authors.
Before adjustment for confounding factors (such as parental influence, social and economic status, and other environmental factors) the researchers observed that the ‘processed’ food pattern was negatively associated with IQ at all ages, while the ‘health-conscious’ pattern at all ages were positively associated with IQ.
However, after adjustment for a wide variety of potential confounding factors, they reported that many associations between IQ and dietary pattern were lost, and those that remained (‘processed’ pattern at three years and ‘health-conscious’ patterns at 8.5 years) “were markedly attenuated”, according to the authors.
For the remaining relationships (after full adjustment) the ‘processed’ food pattern at 3 years was found to be such that a one point increase in the PCA score resulted in an almost two-point decrease in IQ at 8.5 years. Whilst the ‘health-conscious’ pattern was associated with an increased in IQ of 1.20 points per one point increase in PCA pattern score.
Interpretation
Northstone and colleagues said that the results of the study suggest a more “long-term effect of diet on the child’s ability to ‘learn’,” they noted that this could be in part be explained by favourable growth of the brain in early childhood – They noted that it is known that the brain grows at its fastest rate during the first 3 years of life.
“Studies have shown that head growth during this time is associated with cognitive outcome, and it is possible that good nutrition during this early period may encourage optimal brain growth,” said the authors.
However, they added that given the levels of attenuation seen in the effect sizes when adjusted for confounding factors, “we cannot exclude the possibility of residual confounding.”
Source: Journal of Epidemiology and Community Health
Published online ahead of print, doi: 10.1136/jech.2010.111955
“Are dietary patterns in childhood associated with IQ at 8 years of age? A population-based cohort study”
K. Northstone, C. Joinson, P. Emmett, A. Ness, T. Paus
Why Advantig Products Don’t Contain Artificial Colors & Preservatives
Filed under: A Message from the Doctor, Caring for Your Children
Artificial Colors in Kids' Food
Additives like artificial colors & pre
servatives negatively impact brain function
The Lancet 2007, Nov. 3:370(9598) 1560-7. “Food Additives & Hyperactive Behavior in 3 Year old and 8/9 Year Old Children in the Community: A Randomized, Double-Blinded Placebo Controlled Trial.” McCann D., Barrett A., Cooper A., Crumpler D., Dalen L., Grimshaw K., Kitchin E., Lok K., Porteous L., Prince E., Sonuga-Barke E., Warner JO., Stevenson J. School of Psychology, Dept. of Heatlth, University of Southampton, UK. 300 Children Studied.
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From Dr. Schlesser:
Kids are conditioned to select brightly colored products. This extends beyond toys — to foods, which results in consumption of non-nutritive food additives like artificial colors, artificial flavors and preservatives. Published research now confirms that many of these non-nutritive molecules can alter brain function in kids.
This 2007 Lancet Study is a very well-designed, randomized, double-blind, placebo-controlled trial that finally settles the controversy over the impact of non-nutritive food additives on behavior and learning in kids. This trial took place in Great Britain and studied 300 children. The conclusion was that food additives adversely impacted behavior, directly contributing to hyperactive behavior. The findings were so profound that Britain’s Food Standards Agency issued an advisory to parents immediately.
It has been nearly two years since this study’s findings were published and yet there has been no response by the US Government.
For many years, pediatricians have downplayed the impact of artificial colors & preservatives on behavior – even though many parents have been convinced of the link.
American Academy of Pediatrics – Grand Rounds
ADHD & Food Additives Revisited – Alison Schonwold, MD, FAAP, Developmental Medicine Center, Children’s Hospital, Boston, MA, American Academy of Pediatrics, Grand Rounds 2008; 19:17.
ADHD & Non-Nutritive Additives
“The overall findings of the study are clear and require that even we skeptics,
who have long doubted parental claims of the effects of various foods on the
behavior of their children, admit that we might have been wrong.”
From Dr. Schlesser:
Just last year, the American Academy of Pediatrics weighed in on the issue of Artificial Colors and Non-Nutritive Food Additives and after a thorough evaluation of the available scientific literature, including the landmark 2007 study in The Lancet. Their conclusion: “the overall findings of the study are clear and require that even we skeptics who have long doubted parental claims of the effects of various foods on the behavior of their children, admit that we might have been wrong.”
This is an official position statement of the American Academy of Pediatrics.
Do artificial colors have a scientifically justifiable place in our children’s food supply?
We would love to hear your comments.